TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo
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چکیده
منابع مشابه
Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro.
We examined the generation, propagation and pharmacology of 4-aminopyridine (4-AP)-induced epileptiform activity (EA) in the intact interconnected limbic structure of the newborn (P0-7) rat in vitro. Whole-cell recordings of CA3 pyramidal cells and multisite field potential recordings in CA3, CA1, dentate gyrus, and lateral and medial entorhinal cortex revealed 4-AP-induced EA as early as P0-1....
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2013
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2013.10.010